I don't see why not...
Could be an access database for all it cares
Access maybe, but not MySQL or Pervasive SQL. It doesn't read from the ODBC INI entries in the registry, 64 or 32 bit, so one MUST be able to specify a driver that's not already included in the .NET framework EPDM is written with in order to talk to a non-MS database...
The help file for how to query an Excel file gives some hints tho... but I can't figure out what to type to have it understand the connect string in the SQL:
FROM OpenDataSource( 'Microsoft.Jet.OLEDB.4.0',
User ID=Admin;Password=;Extended properties=Excel 8.0')...Sheet1$