No, you cannot. Your best bet is to add your macro buttons to the "S" hot key popup.
I thought I had something for assigning macro to mouse gesture, but all if did was open the macro in the macro editor.
Wayne is correct. This is not supported in SW2011 and earlier. However, this functionality is planned for SW 2012.
9/22/11 Update.... support for macros within mouse gestures was officially done for SW 2012.