I am pretty sure there are a ton of posts in regard to the performance of PDM replicated sites. I'm here to add to it...
I have a PDM setup based in Virginia with a replicated site in Colorado. SQL and main archive lives in Virginia
Latency is around 70-80ms
Link is 1GIG at both locations
PDM 19' SP5
My users often complain of the slow check-in/out, navigation and 'clicks' pretty much anything surrounding anything PDM.
I have thrown new servers, bandwidth, SQL maintenance plans, WAN accelerators (software-based) at this. I have also tried the DB replication, which for me was too buggy to have in production. I have a very small user base downstream, no more than 10 actual writers and 10 read-only users. We never see performance issues in Virginia.
What is everyone else doing to combat this?