Drills and taps can be a mix of metric and inch. If you add a drill or tap to your toolcrib you should see the metric and inch together. below is an example from the stock databases.
You do have the ability with SW CAM Professional to create configurations in CAM the same way as you create SW CAD configurations. This would allow you to setup multiple ops for mill or turn or run a part using different toolcribs. The configs are very versatile like in SW.