Flow Simulation comes included with some great tutorials, in the "Help" section. You should go over those on your own time, look for tutorials involving heat transfer and time-dependent simulation. After you do that, if you have more specific questions I will be happy to help. As it is your request is too vague and boils down to "do this for me."
It looks like your setup is just a transient analysis of natural convection off the walls of your structure. This video goes over the basic setup of a similar analysis (GoEngineer - Transient Natural Convection). Your natural convection will require gravity to work properly and there are some settings for saving steps of the transient result but it is not too difficult to setup.