I guess that depends on whether you want a converged solution or not. Although I'm having a hard time imagining a scenario where you would not want a converged solution.
Exactly what goals to use in not totally clear.
For for the simulations that I run I allways include:
GG Temp of fluid
GG Av Velocity
GG Av Static Pressure
GG Max Temp Solid
GG Avg Total Pressure
and other goals as applicable. For example if you are concerned about radiation then include retaliation goals.
How do you know if you have enough goals? The short answer is if you add more you get the same result as before - you probably have the goals covered. Same logic applies for the amount of mesh to use.
IF solve time is taking ages then in Calculation Control adjust the goals criteria to a percentage - say 5%. Get all the bugs out at 5% then reduce the percentage for final runs. If (for example) there is little difference between 5% and 3% then, 3% would be sufficient.
For non-transient solutions you would not have Physical time ticked.
Refer to the Flow Simulation Online Tutorial for more detail.