I have a very complex model I am working on and having a hard time meshing due to the size of the internal flow channel sizes etc. I am wondering if there is some sort of ball park number for solidworks in general for computation time? Ie I'm not wanting the computer to sit and crunch for days but overnight would be alright once the meshing is done.

I do realize there area a ton of different variables depending on model geometry but I'm wondering if anyone has a ballpark idea of what will bogg a computer down for a week vs maybe 6 hours when converging on a simple flow solution for pressure etc.

Well, it depends on a lot of things. What sort of physics do you have turned on? If you have a transient heat transfer with flow and radiation and long real times it can take a long time. Gernally though you can get pretty good results with modest cell counts but some problems are just inherently large due to geometric complexity. I try to keep them below 10 million and I really don't like them that big - a few million is very workable for most things and 500k is a few hours for most things. I run a 3.3 GHz 12 core dual socket machine with 192 GB of RAM just for reference. Everyone resource limited. Just change the problem to be something you can solve and solve that. You figure out what's important to the answer and simplify the problem to match your resources.