It sounds like a proper CAD computer. The graphics card is an Iris Pro P580, the lack of a discrete graphics card would be my main concern. I couldn't figure out how or where to configure it, but it can hold up to 32GB of memory and has two M.2 slots for storage so any SSD will work in there.

Graphics Card Drivers | SOLIDWORKS says only the Iris Pro P580 (2015 model) and P6300 (2013 server model) are certified. So it's in the list!

Just ran into a review of this thing. It's in Dutch, but Chrome will help you translate. They found the CPU and GPU to be quick, but the cooling wasn't really sufficient to cool the CPU. It would throttle down after reaching 100 deg C and it was really noisy.

https://tweakers.net/reviews/4881/intel-skull-canyon-nuc-als-het-per-se-klein-moet-zijn.html 

This is very intriguing to me.  If nobody has tried it, I might be willing to be a guinea pig.

I don't do anything that's overly intensive in SolidWorks, so I could see this being a perfect portable (not mobile, I don't want a laptop) workstation.  Where do you get $1,300 for this?  I see the NUC itself, plus 16GB memory, an M.2 SSD, and Win10 Pro should put this right around $1,000.

Anyone have any specific reasons NOT to try it?

It's on order, should be here tomorrow (though I don't know when I'll get around to installing/configuring it all).  I got the NUC, 16GB HyperX Impact memory, 512GB Samsung 950 Pro, Windows 10 Pro x64.  I'll be coming from an HP Z210 with an i7-2600 CPU, Quadro 2000, 16GB memory and a 250GB Samsung 850 EVO.  This workstation works fine, but it isn't exactly portable.  Portability is the main draw for me here.

Also, just for fun a lesser spec'd "home" version could come out to around $800, using a 120GB M.2 Samsung EVO, 8GB memory and Windows 10 Home.  Intel does provide a list of tested RAM:  System Memory for Intel® NUC Kit NUC6i7KYK

Feel free to ask any questions if you guys want me to test or benchmark anything.  Most of the SolidWorks work I do is pretty simple, so I imagine I'll have to actually go a little out of my way to try and push the limits.

Price looks reasonable !

I received this today, and got it mostly setup (the basic stuff, at least).

SolidWorks seems to be decently responsive, however system diagnostics is saying that the graphics driver (downloaded from their site) is not supported.

Just a quick update...

I've been using this all week.  So far, it seems fine.  It's pretty snappy and SolidWorks seems to be ok for the most part (haven't really had anything overly complicated though).  The only thing that doesn't work so far is RealView.  My VAR is digging into that for me.

I've been digging a little further into external GPU docs.  Here's what I've found:

The only product available right now that I've found is the Razer Core, but it looks like it's on back order for a couple weeks.  Gigabyte, Asus, PowerColor and AKiTiO all have something in the works that will utilize the Thunderbolt 3 port.  I think the Razer Core looks awesome, just the price tag is a bit higher than I'd personally like.  The AKiTiO Node sounds promising, and I'm actually currently talking to someone from their support team about it.  They said they have tested on this NUC, and that the price should be "very affordable."  No word on a release date, but they did insist that they are not marketing this solely at gamers.  The Asus simply doesn't look like it would fit very well in a professional setting.

I'm going to give this a little time to sort itself out, but I will almost certainly get one of these once they start becoming available.