How do I get rid of these?
Go to System Options > File Locations > Symbol Library File and see where it is pointing to. For some reason it is not finding the Symbol Library File. If there is a location there delete it. Then when you click OK this should come up. Click on Restore default installation folder and see what happens. I think the file name it is looking for is symbols.txt.. Could be wrong.. I will check that. In the pic below I deleted the location and ended up with the same hole callout as you have. When I click restore and exit it changes the callout as it should be.
Edit:... This is where my location is. The file name it is searching for is Symbol.txt
Retrieving data ...