I have an issue below and thought someone else might have experienced and can share their thoughts too.
I built a simple Add-in using this link from Help (below) and set the .NET Framework to latest (4.5). But when I click on the menu "First Command", it does not display the message boxes. And if I change the .NET to 2.0, it works. I need to make it work with .NET 4.5 because I have some dependant 3rd party dll's which don't work on older .NET.
My environment: Visual Studio 2013 & EPDM 2016 Sp2